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Dr. Lindsey Goff

 

Dr. Lindsey Goff has a BSc in physiology and an MSc in immunology from the University of London. She gained her PhD at the Cancer Research UK, Tumour Immunology Unit in London studying the role of different CD45 (PTPRC) isoforms in the developing thymus.

 

Lindsey’s career spans 25 years with Cancer Research UK. At first she studied T- and B- cell development and immune response to tumour antigens. In addition to the more standard techniques, during this phase, she also carried out foetal thymic organ culture, multiparameter flow cytometry, yeast artificial chromosome analysis and transfection of high molecular weight DNA.

 

Later with her move to the Medical Oncology Department at St Bartholomew’s Hospital, London, Lindsey’s focus shifted from basic immunology to studying malignancies of immune cells. She studied the evolution and molecular biology of leukaemias and B-cell lymphomas and how they impact on the local immune system. Lindsey specialised in detection of low-level disease using tumour-specific molecular techniques, and, as well as developing novel real-time PCR assays for chromosomal breakpoints and fusion proteins, she also investigated the use of the characteristic follicular lymphoma t(14;18) rearrangement as a predictor of disease relapse. To analyse the tumour immune microenvironment Lindsey used histopathological techniques and tissue microarray. A large archive of patient samples with complete medical history meant that she was able to correlate clinical outcome with molecular and histopathological features. 

 

Alongside her career at the bench, during which she published over 30 scientific reports, Lindsey has taken courses in journalism and proofreading. As well as being experienced in writing and editing manuscripts she has also edited immunology textbooks and written scientific articles for web and printed publication.

 

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